Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869
  • 44th Annual Gross Review Course

    Learn all about gross lesions in domestic, laboratory, and exotic animals.

  • 2017 Current Lab Animal Science Seminar / Pathology of Lab Animals Course

    Recognize and interpret conditions which may affect experimental results or alter the health of laboratory animals.

  • Annual Diagnostic Pathology Symposium: Diagnostic Renal Pathology

    Learn about glomerular pathology, glomerular ultrastructure, and pathology of tubulointerstitial disease.

  • Annual Zoo & Wildlife Pathology Workshop

    The theme of this year is fungal diseases.

  • Argentinean Division Seminar

    Dr. Donal O'Toole (second from left) is demonstrating lesions, and Dr. Melissa Macias (second from right) is translating into Spanish at the 10th seminar of the Argentinean Division of the Foundation.

  • Chilean Seminar

    Participants of the 4th Chilean Seminar of the Foundation on the campus of the University of Chile in Santiago de Chile in August 2016.

  • European Symposium

    The European Symposium of the Foundation was held in Bologna, Italy, in September 2016.

  • Northeast Day Seminar

    Janssen R&D (J&J Pharmaceuticals) and the Davis-Thompson sponsored and hosted the Northeast Day Seminar at Spring House, Pennsylvania in September 2016.

Most Requested Publications

We are currently having problems with our bookstore, and we are sorry for the inconvenience. Please call the Main Office at 847-367-4359 to place all orders, and they will be shipped immediately. This problem should be resolved within the month.

CE Portal

Course ID: 166312
Title: Pathology of the Musculoskeletal System of the Dog


Length: 00:45:00
Author: Dr Bruce Williams DVM
Description: This RACE-accredited lecture discusses the pathologic features of the musculoskeletal system of the dog.

Noah's Arkive

The Foundation is proud to make Noah's Arkive, a searchable collection of veterinary pathology images, available online at no cost. Special thanks to the University of Georgia for transferring the database and image collection to the Foundation!

Random Image:

CL Davis Diagnostic Exercises

The main goal of these Diagnostic Exercises is to provide interesting cases, focusing on the gross pathological lesions and associated histopathologic or cytologic findings. This material can be of great use for veterinary students, in-training pathologists, and ACVP diplomates alike.

There will be one contribution per month of the year; anyone may contribute. To do so, please contact Dr. Vinicius Carreira at vinicius.carreira@gmail.com to identify a convenient date for your submission and to receive templates to be used. Spots will be filled out on a first-come first-served basis.

Exercise Thumbnail Answer
Click here for case history Click here for case synopsis

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New today in Noah - from the AFIP Archive.

Tissue from a young rhesus macaque.

Note the white spot on the tongue. Histologically, this is a focal vesicle with a hyperkeratotic roof. Known in human medicine as a "Koplik spot" (first described by Dr. Koplik in 1896, it is a prodromal sign of imminent measles infection. The characteristic skin rash appears about 3 days later in people.

In humans, these are generally seen in the buccal mucosa at the level of the molars, but in Old World monkeys, they may be gingival, buccal, or lingual. They are inconsistent and not present in every case. Referred to as an "exanthem" (a word I don't understand very well), these vesicles are parakeratotic on top (giving them a bluish color in real life) and largely devoid of inflammation. There are no giant cell syncytia which characterize the lesion seen days later in the skin, lungs, lymph nodes, and other organs.

Remember the course of measles varies greatly between Old and New World monkeys (who have an often fatal enteritis).

I want to credit this image to Dr. Gary Baskin (in whose lectures I first saw it), but I'm not exactly sure. When he was at the Delta Primate Center in New Orleans, he was the man when it came to primates (and described SIV in a wonderful series of papers when it was first discovered in the late 1980s), and a great lecturer.
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New today on Noah' Arkive - from the AFIP Archive.

Tissue from a rat.

Note the yellow-gold color of the kidney - with the exception of cats, who often put a lot of fat into the loop of Henle, the kidney of pretty much every other species is a nice brick red color, due to the extensive vascularity (the glomeruli are the largest capillary bed in the body). So whenever I see a golden color, that's a pretty sick kidney. Then the granularity is a dead giveaway.

This is a classic cases of chronic progressive nephropathy of old rats. Most rats on chronic studies have some degree, and the worst cases are seen in Sprague-Dawleys and Fischers 344s. There are lesions at all levels of the nephron at this point - severe interstitial fibrosis, ectasis, proteinosis, atrophy, and loss of tubules, and extensive glomerular changes including synechiae and sclerosis.

Remember that if you effect one area of the nephron, you eventually affect the entire nephron, so severe tubular changes will eventually result in glomerular changes, and vice versa. In CPN, the earliest morphologic changes begin around 3-4 months in the tubules, but as they approach 18 mos or 24 months, every segment is a mess.

Over the years, many different etiologies have been proposed - genetics, diet, antibody deposition, complement fixation, and it likely is multifactorial. And rats aren't alone - they just have the best cases. Every type of old rodent - mice, hamsters, gerbils, guinea pigs - have some form of chronic nephropathy - they all differ a bit in the manifestation.

Pet rats are no different - we see it in every beloved ancient pet rat we see.
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New today in Noah's Arkive from Guillermo Rimoldi of the Clemson University Diagnostic Lab..

Tissue from an ox.

From Guillermo: "Histophilosis (Histophilus somni) is a common disease of cattle, in particular feedlot animals. H somni often causes acute, fatal septicemic disease that primarily affects the lungs, heart and central nervorus system. The disease is also called Thromboembolic Meningoencephalitis (aka TEME) due to the morphological lesions in the brain stem."
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